Hormonal Variation
- AIS (androgen insensitivity syndrome)
- people who have XY (male) chromosomes, but they are insensitive to androgens (male hormones) like testosterone. - So this male has testes that excrete testosterone but do not have sufficient receptors for regular development
-This can effect internal reproductive organs, (the wolfian duct)
- This can effect external structures, instead of a penis is born with female sex organs
Hormonal Variation
Androgen Insensitivity Syndrome (AIS)
-disorder of the adrenal gland - produces adrenaline
-girls have XX chromosomes, with this condition they will have normal internal female parts
- external can be ambiguous
- Can develop facial hair, early puberty, deep voice
-Much higher level of interest in male activity
- There is often more homosexual fantasies - then without girls with CHH
- Males don't have hormone receptors, so they grow female external parts
Congenital Insensitivity Syndrome (CAH)
-Medical intervention may need to be taken
- 1 in 15000 have condition
- Can go through puberty before the age of 1 - though not mentally mature
DHT deficient males
-Infants born that have not been producing adequate part of DHT
-May have external genitalia that looks female
-Penis may appear very small
- Urethra may be half down a penis - instead of tip
- Papa New Guinea, and Egypt is where the mutation occured
- Often raised as girls, though often feels as boys.
- During puberty causes penis to grow - clitoris grows into penis, testes will descend
called guevedochie
- They were studied, could easily adjust
Abliato Penis
- 2 identical twin boys, - one had its penis cut off, had a vagina reconstructed
- Did not feel like a girl, had to take hormones and once hit puberty refused to act and socialize in feminine ways
Chromosomal Variations
- Turners Syndrome (only born with X chromosome)
- By the age of 5 they are abnormally short - ovaries development starts but can not be completed
- At puberty breasts do not develop
- 1 - 25000, born with turners syndrome
Klinefelter's Syndrome
-XX and one Y
-at birth classified as male, small testes, not enough testosterone to maintain a male body
-Penis is small
-At puberty when more testosterone is produced, they is female physical features magnified.
-Breasts enlarged, less body hair - Infertility
-Sex drive is lower
-Learning disabilities, problems with development of speech and language
-1 in 500- 1000
XYY males - Jacobs syndrome
-late development of motor skills
-sex organs look typically male
- typically more active males
- Some atheletes have different sex chromosomes
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